In vitro metabolic stability of iodinated obestatin peptides

wim — Tue, 05 Feb 2013 12:14:36 +0000

B. De Spiegeleer, S. Van Dorpe, V. Vergote, E. Wynendaele, E. Pauwels, C. Van de Wiele, J.E. Garcıa-Ramos, J.C. Solis-Sainz

Peptides

33 (2), 272-278

2012

Abstract

Natriuretic peptides are endogenous hormones released by the heart in response to myocardial stretch and overload. While atrial and brain natriuretic peptides (ANP, BNP) were immediately considered cardiac hormones and their role was well-characterized and defined in predicting risk in cardiovascular disease, evidence indicating the role of C-type natriuretic peptide (CNP) in cardiovascular regulation was slow to emerge until about 8 years ago. Since then, considerable literature on CNP and the cardiovascular system has been published; the aim of this review is to examine current literature relating to CNP and cardiovascular disease, in particular its role in heart failure (HF) and myocardial infarction (MI). This review retraces the fundamental steps in research that led understanding the role of CNP in HF and MI; from increased CNP mRNA expression and plasmatic concentrations in humans and in animal models, to detection of CNP expression in cardiomyocytes, to its evaluation in human leukocytes. The traditional view of CNP as an endothelial peptide has been surpassed by the results of many studies published in recent years, and while its physiological role is still under investigation, information is now available regarding its contribution to cardiovascular function. Taken together, these observations suggest that CNP and its specific receptor, NPR-B, can play a very important role in regulating cardiac hypertrophy and remodeling, indicating NPR-B as a new potential drug target for the treatment of cardiovascular disease.

Open Access version available at UGent repository

DOI

http://dx.doi.org/10.1016/j.peptides.2012.12.010

Private attachment

12_Peptides_33(2)272_DeSpiegeleer.pdf

The metabolisation of different iodinated peptide species

wim — Mon, 17 Oct 2011 14:17:18 +0000

B. De Spiegeleer, S. Van Dorpe, E. Pauwels

Poster

Conference / event / venue

31st European Peptide Symposium

Copenhagen, Denmark

Sunday, 5 September, 2010 to Thursday, 9 September, 2010

HPLC-MS characterisation of chelate modified somatropin

wim — Mon, 17 Oct 2011 14:06:31 +0000

E. Wynendaele, E. Pauwels, S. Van Dorpe, V. Vergote, C. Van de Wiele, B. De Spiegeleer

Poster

Conference / event / venue

10th Flemish youth conference of chemistry

Blankenberge, Belgium

Monday, 1 March, 2010 to Tuesday, 2 March, 2010

Abstract

2010_VJC_Evelien.pdf

Center for Molecular Modeling - S. Van Dorpe

In vitro metabolic stability of iodinated obestatin peptides

Abstract

DOI

Private attachment

The metabolisation of different iodinated peptide species

Conference / event / venue

HPLC-MS characterisation of chelate modified somatropin

Conference / event / venue

Abstract