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Structural basis of the proinflammatory signaling complex mediated by TSLP

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K. Verstraete, L. van Schie, L. Vyncke, Y. Bloch, J. Tavernier, E. Pauwels, F. Peelman, S.N. Savvides, A. Bronselaer
Nature Structural & Molecular Biology
21 (2014), 375–382
2014
A1

Abstract 

Thymic stromal lymphopoietin (TSLP) is a cytokine critical for the development of chronic inflammatory disorders including asthma and atopic dermatitis. The structure of the ternary complex formed by TSLP and its coreceptors TSLPR and the interleukin-7 receptor reveal how TSLP is able to organize receptor-receptor contacts to facilitate intracellular signaling.

DOI 

http://dx.doi.org/10.1038/nsmb.2794

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PDF icon 14_Nature_Struct&Mol_Bio_xxxx_Verstraete.pdf

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